MK-677 YK-11 LGD-4033 Triple Stack

Description

MK-677 YK-11 LGD-4033 triple stack buyers get three bottles from matched, tested batches: MK-677 25mg/mL, YK-11 10mg/mL and LGD-4033 10mg/mL. Sports Technology Labs supplies it for in-vitro research only.

The compounds in the MK-677 YK-11 LGD-4033 triple stack

MK-677 (ibutamoren) is an orally active, nonpeptide growth hormone secretagogue developed by Merck. It mimics ghrelin at the GHS-R1a receptor, raising growth hormone and IGF-1. It’s often sold next to SARMs, but it isn’t one.

YK-11 is a steroidal compound built on a dihydrotestosterone backbone, first described by Japanese researchers in 2011. It’s usually sold next to SARMs, but it’s a steroid and only a partial agonist at the androgen receptor.

LGD-4033 (ligandrol, also coded VK5211) is a nonsteroidal SARM discovered by Ligand Pharmaceuticals and later licensed to Viking Therapeutics. It binds the androgen receptor with high affinity and, in animal models, acts strongly on muscle and bone while sparing the prostate.

The reasoning behind the MK-677 YK-11 LGD-4033 triple stack

The compounds in this stack don’t overlap: MK-677 is an oral ghrelin mimic that raises GH and IGF-1 and isn’t a SARM, YK-11 is a steroidal partial agonist linked to follistatin in cell studies and LGD-4033 binds the androgen receptor very tightly and has a phase 1 study in healthy men. Labs that want to look at more than one pathway in the same model often order them together, and buying them as a set keeps the batches matched.

Because each compound comes in its own container, you can measure them independently and change the ratio between experiments.

Mechanisms in the MK-677 YK-11 LGD-4033 triple stack

MK-677 binds GHS-R1a, the same receptor as ghrelin and the GHRP peptides, in the pituitary and hypothalamus. That boosts the size of natural GH pulses and lifts IGF-1 from the liver.

YK-11 binds the androgen receptor but doesn’t trigger the full shape change that DHT does, so it activates only part of the usual gene program. That’s why it’s called a partial agonist.

Like other SARMs, LGD-4033 binds the androgen receptor and the receptor complex moves into the nucleus to switch on androgen-responsive genes. Its binding is unusually tight, with a reported Ki around 1 nanomolar.

MK-677 YK-11 LGD-4033 triple stack product details

• MK-677 (ibutamoren), 25mg/mL in a 30mL bottle, 99.87% by HPLC (CAS 159634-47-6, C27H36N4O5S, 528.7 g/mol)
• YK-11, 10mg/mL in a 30mL bottle, 99.04% by HPLC (CAS 1370003-76-1, C25H34O6, 430.5 g/mol)
• LGD-4033 (ligandrol), 10mg/mL in a 30mL bottle, 97.25% by HPLC (CAS 1165910-22-4, C14H12F6N2O, 338.3 g/mol)
• Form: liquid in USP-grade PEG-400, graduated 1mL glass pipette with each bottle
• Tested by: MZ Biolabs, Tucson, Arizona
• SKU: STL-MK-YK-LGD
• Intended use: laboratory research only

Published studies on the MK-677 YK-11 LGD-4033 triple stack compounds

Nass and colleagues ran a two-year trial in healthy older adults, published in the Annals of Internal Medicine in 2008. MK-677 raised GH and IGF-1 to levels seen in young adults and increased fat-free mass, with rises in fasting glucose noted.

Kanno and colleagues showed in Biological and Pharmaceutical Bulletin in 2013 that YK-11 drove muscle cell differentiation in C2C12 myoblasts more strongly than DHT and raised follistatin expression.

A phase 1 study by Basaria and colleagues, published in the Journals of Gerontology in 2013, gave LGD-4033 to 76 healthy young men for 21 days. Lean body mass rose with the dose, and the study also reported dose-related drops in HDL cholesterol and testosterone.

All of these studies are indexed on PubMed. This combined search pulls them up.

How Sports Technology Labs tests MK-677 YK-11 LGD-4033 triple stack

The current certificates of analysis show MK-677 at 99.87%, YK-11 at 99.04% and LGD-4033 at 97.25% by HPLC. The testing is done by MZ Biolabs, an independent lab in Tucson, Arizona, which also checks identity by mass spectrometry.

You’ll find the COA in the photo gallery above. Open it and check the date, the method and the purity figure yourself.

HPLC and mass spec answer different questions. HPLC tells you what share of the sample is the main compound. Mass spec tells you the compound is the right molecule. A COA with only one of them leaves a gap.

Orders are covered by a 60-day money-back guarantee.

Measuring and storing the MK-677 YK-11 LGD-4033 triple stack

Every bottle is 30mL with a graduated 1mL glass pipette. Since the strengths differ, label which pipette belongs to which bottle:

• MK-677 at 25mg/mL: 1mL holds 25mg, 750mg per bottle
• YK-11 at 10mg/mL: 1mL holds 10mg, 300mg per bottle
• LGD-4033 at 10mg/mL: 1mL holds 10mg, 300mg per bottle

PEG-400 is thicker than water, so draw slowly and let the pipette drain. Store the bottles capped in a cool, dry place out of direct light.

More from our SARM stacks

• LGD-4033 and MK-677 Stack, two bottles in one order
• RAD-140 and LGD-4033 Stack, two bottles in one order
• Ostarine Cardarine SR-9009 Triple Stack, three bottles in one order
• RAD-140 and RU-58841 Stack, two bottles in one order
• LGD-4033 and YK-11 Stack, two bottles in one order

The rest of the range is in our SARM stacks and SARMs for sale. Every section of the store is linked from the Sports Technology Labs home page.

MK-677 YK-11 LGD-4033 triple stack questions and answers

What’s in the MK-677 YK-11 LGD-4033 triple stack?

MK-677 25mg/mL, YK-11 10mg/mL and LGD-4033 10mg/mL, as three separate bottles.

Can I buy the MK-677 YK-11 LGD-4033 triple stack compounds separately?

Yes: MK-677, YK-11 and LGD-4033.

How should the MK-677 YK-11 LGD-4033 triple stack be stored?

Capped, in a cool, dry place out of direct light.

Can the MK-677 YK-11 LGD-4033 triple stack be used in people or animals?

No. Sports Technology Labs sells it for laboratory research only. It isn’t approved for human or veterinary use.

Is the MK-677 YK-11 LGD-4033 triple stack in stock?

Yes, it’s in stock now, and shipping is free.

Order MK-677 YK-11 LGD-4033 triple stack online today

Ready to order? MK-677 YK-11 LGD-4033 triple stack costs $195.99, it’s in stock and shipping is free. Paying in crypto takes 15% off.

Building a bigger order? See our SARM stacks and SARMs for sale.

Sports Technology Labs sells this product for laboratory and in-vitro research only. It isn’t a medicine, food or dietary supplement, and it must not be given to people or animals. The FDA has not evaluated any statement on this page. MK-677, YK-11 and LGD-4033 are on the World Anti-Doping Agency prohibited list (S1.2, anabolic agents and S2, peptide hormones, growth factors and mimetics), so tested athletes should not handle them outside a lab. Buyers must be 21 or older.